
The rune64.dll error is a common issue encountered by players trying to launch GTA 5 Enhanced Edition on PC. This error typically occurs when essential game files are missing, corrupted, or blocked by third-party software, preventing the game from starting. You may encounter messages such as: "rune64.dll is missing", "The program can't start because rune64.dll was not found", or "Error loading rune64.dll". When this happens, the game may crash on startup or refuse to launch entirely. Fortunately, the issue can be fixed with several reliable solutions. This article will guide you through various methods to resolve the rune64.dll error and get GTA 5 running again.
Method 1: Verify Game Files
One of the simplest ways to fix the rune64.dll error is by verifying the integrity of the game files. This process will automatically detect and restore any corrupted or missing files.
Open Steam and go to Library
Right-click on GTA 5 Enhanced Edition and select Properties
Under the Installed Files tab, click Verify Integrity of Game Files
Steam will check for missing or corrupted files and replace them
Epic Games Launcher
Open the Epic Games Launcher
Go to Library
Click the three dots next to GTA 5 and select Manage
Choose Verify to check and restore missing files
Rockstar Games Launcher
Open Rockstar Games Launcher
Go to Settings
Select GTA 5 under My Installed Games
Click Verify Integrity
Once the verification process is complete, try launching GTA 5 again.

Method 2: Using an Automated DLL Repair Tool
If the error persists even after verifying the game files, an automated DLL repair tool like PcGoGo DLL Fixer can help restore missing or corrupted DLL files quickly and easily.
Download and install PcGoGo DLL Fixer
Open the program once installed
Run a Full System Scan to detect damaged or missing DLL files
After the scan finishes, click Repair Now to restore the correct version of rune64.dll
Restart your PC and launch GTA 5 again
This solution is perfect for users looking for a fast, beginner-friendly fix without having to manually troubleshoot.

Method 3: Reinstall or Update Visual C++ Redistributables
GTA 5 Enhanced Edition heavily relies on Visual C++ Redistributables. If these components are outdated or corrupted, you may encounter errors related to missing or damaged DLL files.
Visit the Microsoft Visual C++ Redistributable download page
Download and install the appropriate versions (particularly 2015–2022)
Restart your computer
Try launching GTA 5 again
Updating these components often resolves DLL errors, including rune64.dll.

Method 4: Disable or Remove Problematic Mods
Outdated or incompatible mods can interfere with the game files and cause errors. If you're using mods, they may be the culprit behind the rune64.dll error.
Temporarily remove the mods folder from the GTA 5 directory
Delete or rename any dinput8.dll files or mod loader files that might be causing issues
Restart the game without any mods to see if the error is resolved
If the game launches without the mods, you will need to update or remove the problematic mod
Method 5: Add the GTA 5 Folder to Antivirus Exclusions
Sometimes, antivirus software can mistakenly flag DLL files as threats and block them, causing errors like rune64.dll missing.
Open your antivirus program or Windows Security
Go to Virus & threat protection settings
Select Manage settings → Add or remove exclusions
Add the entire GTA 5 installation folder to the exclusions list
Restore any quarantined files if necessary
After whitelisting the folder, try launching the game again

Method 6: Update Windows
Ensure your Windows system is up to date. Windows updates can include fixes for known issues and replace missing components needed by the game.
Open Settings and go to Update & Security
Click Check for updates and install all available updates
Restart your system and try running GTA 5 again

Method 7: Perform System File Repair (SFC & DISM)
Corrupted system files can sometimes prevent DLL files from loading properly.
Open Command Prompt as Administrator
Run the following command:
sfc /scannow
After the scan completes, if the issue persists, run the following DISM commands:
DISM /Online /Cleanup-Image /ScanHealth
DISM /Online /Cleanup-Image /RestoreHealth
Restart your computer
These tools repair corrupted system components that may be affecting the game files.

Prevention Tips
To prevent rune64.dll and similar issues in the future:
Keep your game and mods updated
Avoid downloading DLL files from untrusted sources
Perform regular system maintenance (e.g., disk cleanup, update drivers)
Backup your game files to restore them in case of corruption

Common Causes of rune64.dll Error
The error is usually caused by one or more of the following factors:
Missing or corrupted rune64.dll: The file itself may be corrupted or accidentally deleted
Outdated or incompatible mods: Mods often interfere with game files, causing DLL issues
Damaged Visual C++ Redistributables: GTA 5 relies on Microsoft's Visual C++ packages, and if they are not updated or corrupted, the game may fail to launch
Antivirus software blocking DLL files: Antivirus programs can falsely flag important game files as threats and quarantine them
Incomplete or corrupted game installation: Sometimes, the installation process does not complete successfully, leaving essential files missing or corrupted
Windows system file corruption: Corrupted system files can also lead to errors with DLL files
Conclusion
The rune64.dll error in GTA 5 Enhanced Edition is typically caused by missing, corrupted, or blocked DLL files. Fortunately, resolving the issue is straightforward using the methods outlined in this guide. From verifying game files to updating system components, or even using automated DLL repair tools, you can fix this problem quickly. By following these steps, you can enjoy GTA 5 without further interruption.